Patent
1. Le Zhang, Tingting Li, Nan Hu, Xiaoyu He. A gene, singaling pathway and related protein slection algorihtm for hign dimension low sample data. Vol. ZL 2016 1 0734417. X (China, 2016).

2. Le Zhang, Meijing Kong. A confirmation method of myeloma signaling pathway mechanism based on modular factor graph. 201610846098.1 (China, 2016).

3. Le Zhang. A analytical method for colorectal cancer data model based on genetic and environmental correlation. 201610953314.2 (China, 2016).

4. Le Zhang, Hongjie Gao. A multi-scale drug coordination prediction method based on Agent. ZL  2017 1 156248.7 (China, 2017).

5. Le Zhang, Ming Xiao. The method and system for multi-species unappeared k-mer subsequence calculating and characteristic analysis. ZL 2018 1 0207512.3 (China, 2018).

6. Le Zhang, Jingxing Chen, Weilong Ding, Chenyang Jing, Jiping Feng. The codon bias coefficient model method based on CPU-GPU heterogeneous composite parallel computing framework. China patent ZL 2017 1 0332575.7. 2017.

7. Le Zhang, Kaikai Yin, Jiakun Li. The method and system for establishing a cerebral hemorrhage prediction model based on ensemble learning. China patent ZL 201710691118.7.2017.

Research Papers
1. Zhang L, Zhang L, Guo Y, Xiao M, Feng L, Yang C, et al. MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction. Acta Pharmaceutica Sinica B. 2021. doi: 10.1016/j.apsb.2021.05.032.
2. Zhang L, Zhao J, Bi H, Yang X, Zhang Z, Su Y, et al. Bioinformatic analysis of chromatin organization and biased expression of duplicated genes between two poplars with a common whole-genome duplication. Horticulture Research. 2021;8(1). doi: 10.1038/s41438-021-00494-2. (IF:5.404)
3. Zhang L, Dai Z, Yu J, Xiao M. CpG-island-based annotation and analysis of human housekeeping genes. Brief Bioinform. 2021;22(1):515-25. Epub 2020/01/27. doi: 10.1093/bib/bbz134. (IF:8.99)
4. Xiao M, Liu G, Xie J, Dai Z, Wei Z, Ren Z, et al. 2019nCoVAS: Developing the Web Service for Epidemic Transmission Prediction, Genome Analysis, and Psychological Stress Assessment for 2019-nCoV. IEEE/ACM Trans Comput Biol Bioinform. 2021; Epub 2021/01/07. doi: 10.1109/TCBB.2021.3049617. （CCF B）
5. Gao J, Liu P, Liu G, Zhang L. Robust needle localization and enhancement algorithm for ultrasound by deep learning and beam steering methods. Journal of Computer Science and Technology. 2021;36(2):334-6. doi: 10.1007/s11390-021-0861-7. （CCF B）
6. Xiao M, Yang X, Yu J, Zhang L. CGIDLA:Developing the Web Server for CpG Island Related Density and LAUPs (Lineage-Associated Underrepresented Permutations) Study. IEEE/ACM Trans Comput Biol Bioinform. 2020;17(6):2148-54. Epub 2019/08/24. doi: 10.1109/TCBB.2019.2935971. （CCF B）
7. Liu G-D, Li Y-C, Zhang W, Zhang L. A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders. Engineering. 2020;6(4):462-7. doi: 10.1016/j.eng.2019.06.008. (IF:6.495)
8. Zhang L, Liu G, Kong M, Li T, Wu D, Zhou X, et al. Revealing dynamic regulations and the related key proteins of myeloma-initiating cells by integrating experimental data into a systems biological model. Bioinformatics. 2019. Epub 2019/07/28. doi: 10.1093/bioinformatics/btz542. (IF:5.61)
9. Zhang L, Bai W, Yuan N, Du Z. Comprehensively benchmarking applications for detecting copy number variation. PLoS Comput Biol. 2019;15(5):e1007069. doi: 10.1371/journal.pcbi.1007069. (IF: 4.7)
10. Zhang L, Xiao M, Zhou J, Yu J. Lineage-associated underrepresented permutations (LAUPs) of mammalian genomic sequences based on a Jellyfish-based LAUPs analysis application (JBLA). Bioinformatics. 2018;34(21):3624-30. Epub 2018/05/16. doi: 10.1093/bioinformatics/bty392. (IF: 5.61)
11. Zhang L, Zheng CQ, Li T, Xing L, Zeng H, Li TT, et al. Building Up a Robust Risk Mathematical Platform to Predict Colorectal Cancer. Complexity. 2017;2017:14. doi: Artn 891725810.1155/2017/8917258. (IF:2.462)
12. Zhang L, Zhang S. Using game theory to investigate the epigenetic control mechanisms of embryo development: Comment on: "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev. 2017;20:140-2. Epub 2017/01/23. doi: 10.1016/j.plrev.2017.01.007. (IF:4.789)
13. Zhang L, Liu Y, Wang M, Wu Z, Li N, Zhang J, et al. EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients. J Mol Cell Biol. 2017;9(6):477-88. Epub 2017/12/23. doi: 10.1093/jmcb/mjx056. (IF:4)
14. Zhang L, Qiao M, Gao H, Hu B, Tan H, Zhou X, et al. Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation. Nanoscale. 2016;8(31):14877-87. Epub 2016/07/28. doi: 10.1039/c6nr01637e. (IF:6.895)
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