Patent
1. Le Zhang, Tingting Li, Nan Hu, Xiaoyu He. A gene, singaling pathway and related protein slection algorihtm for hign dimension low sample data. Vol. ZL 2016 1 0734417. X (China, 2016).

2. Le Zhang, Meijing Kong. A confirmation method of myeloma signaling pathway mechanism based on modular factor graph. 201610846098.1 (China, 2016).

3. Le Zhang. A analytical method for colorectal cancer data model based on genetic and environmental correlation. 201610953314.2 (China, 2016).

4. Le Zhang, Hongjie Gao. A multi-scale drug coordination prediction method based on Agent. ZL  2017 1 156248.7 (China, 2017).

5. Le Zhang, Ming Xiao. The method and system for multi-species unappeared k-mer subsequence calculating and characteristic analysis. ZL 2018 1 0207512.3 (China, 2018).

6. Le Zhang, Jingxing Chen, Weilong Ding, Chenyang Jing, Jiping Feng. The codon bias coefficient model method based on CPU-GPU heterogeneous composite parallel computing framework. China patent ZL 2017 1 0332575.7. 2017.

7. Le Zhang, Kaikai Yin, Jiakun Li. The method and system for establishing a cerebral hemorrhage prediction model based on ensemble learning. China patent ZL 201710691118.7.2017.

8. Le Zhang, WenTing Wu, HongTu Li. Calculation method and device of the relationship between high-risk HPV type and precancerous stage of cervical cancer. China patent ZL 2019 11420979.7

9. Le Zhang, Lei Zhang, Ji Lv. Method, system and device for establishing the model of action mechanism of traditional Chinese medicine based on network pharmacology. China patent ZL 2020 10260328.2

10. Le Zhang, Yujie You, Yujie Chen. Method and system for screening high-dimensional and low-sample gene data and protein network analysis. China patent ZL 2019 11424402.3

11. Le Zhang, Guangdi Liu, Jingxiang Liu, Wei Zhang, Yuchen Li, Yue Wang. Mental health comprehensive adaptive assessment method and system. China patent ZL 2020 11351547.8

12. Le Zhang, Yangchao Yu, Bing Li. BLAST acceleration method and system for gene search based on quantum technology. China patent ZL 2023 11254777.6

13. Le Zhang, et al. Method and system of recurrence and metastasis analysis model based on multi-omics data. China patent ZL 2022 11198172.5

14. Le Zhang, et al. A linear equation acceleration method and system based on quantum computing. China patent ZL 2022 1 1427010.4

15. Le Zhang, Yiming Yue, Yujie You, Ming Xiao, Lei Zhang, Qichen Shang. A quantum computing error correction method. China patent ZL 2022 1 1427009.1

Research Papers
Gao Jun, Lao Qicheng, Qingbo Kang, Liu Paul, Du Chenlin, Li Kang, Zhang Le*. (2024). Boosting Your Context by Dual Similarity Checkup for In-Context Learning Medical Image Segmentation. IEEE transactions on medical imaging. PP. 10.1109/TMI.2024.3440311. (IF:8.9)
Xiao M, Wei R, Yu J, Gao C, Yang F, Zhang L*. CpG island definition and methylation mapping of the T2T-YAO genome. Genomics, Proteomics & Bioinformatics. 2024. doi: 10.1093/gpbjnl/qzae009. (IF: 9.5)
L. Zhang, W. Song, T. Zhu, Y. Liu, W. Chen, and Y. Cao, "ConvNeXt-MHC: improving MHC–peptide affinity prediction by structure-derived degenerate coding and the ConvNeXt model," Briefings in Bioinformatics, vol. 25, no. 3, p. , 2024. (IF:9.5)
Gao J, Lao Q, Liu P, Yi H, Kang Q, Jiang Z, Zhang L*et al. Anatomically Guided Cross-Domain Repair and Screening for Ultrasound Fetal Biometry. IEEE Journal of Biomedical and Health Informatics. 2023:1-12. doi: 10.1109/JBHI.2023.3298096. (IF:7.7)
You Y, Lai X, Pan Y, Zheng H, Vera J, Liu S, Zhang L*et al. Artificial intelligence in cancer target identification and drug discovery. Signal Transduct Target Ther. 2022;7(1):156. Epub 2022/05/11. doi: 10.1038/s41392-022-00994-0. PubMed PMID: 35538061; PubMed Central PMCID: PMCPMC9090746. (IF:39.4)
Song H, Chen L, Cui Y, Li Q, Wang Q, Fan J, Zhang L*et al. Denoising of MR and CT images using cascaded multi-supervision convolutional neural networks with progressive training. Neurocomputing. 2022;469:354-65. doi: 10.1016/j.neucom.2020.10.118. PubMed PMID: WOS:000761794800004. (IF:6)
Lai X, Zhou J, Wessely A, Heppt M, Maier A, Berking C, Zhang L* et al. A disease network-based deep learning approach for characterizing melanoma. Int J Cancer. 2022;150(6):1029-44. Epub 2021/10/31. doi: 10.1002/ijc.33860. PubMed PMID: 34716589. (IF:6.4)
Zhang L, Zhao J, Bi H, Yang X, Zhang Z, Su Y, et al. Bioinformatic analysis of chromatin organization and biased expression of duplicated genes between two poplars with a common whole-genome duplication. Hortic Res. 2021;8(1):62. Epub 2021/03/23. doi: 10.1038/s41438-021-00494-2. PubMed PMID: 33750794; PubMed Central PMCID: PMCPMC7943600. (IF:8.7)
Zhang L, Zhang L, Guo Y, Xiao M, Feng L, Yang C, et al. MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction. Acta Pharm Sin B. 2021;11(10):3092-104. Epub 2021/11/04. doi: 10.1016/j.apsb.2021.05.032. PubMed PMID: 34729303; PubMed Central PMCID: PMCPMC8546929. (IF:14.5)
Zhang L, Liu G, Kong M, Li T, Wu D, Zhou X, et al. Revealing dynamic regulations and the related key proteins of myeloma-initiating cells by integrating experimental data into a systems biological model. Bioinformatics. 2021;37(11):1554-61. Epub 2019/07/28. doi: 10.1093/bioinformatics/btz542. PubMed PMID: 31350562; PubMed Central PMCID: PMCPMC8485849. (IF:5.8)
Zhang L, Dai Z, Yu J, Xiao M. CpG-island-based annotation and analysis of human housekeeping genes. Brief Bioinform. 2021;22(1):515-25. Epub 2020/01/27. doi: 10.1093/bib/bbz134. PubMed PMID: 31982909. (IF:9.5)
Liu G-D, Li Y-C, Zhang W, Zhang L*. A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders. Engineering-Prc. 2020;6(4):462-7. doi: 10.1016/j.eng.2019.06.008. PubMed PMID: WOS:000537705900015. (IF:12.8)
Zhang L, Bai W, Yuan N, Du Z. Comprehensively benchmarking applications for detecting copy number variation. PLoS Comput Biol. 2019;15(5):e1007069. Epub 2019/05/29. doi: 10.1371/journal.pcbi.1007069. PubMed PMID: 31136576; PubMed Central PMCID: PMCPMC6555534 Zdmedical, Information Polytron Technologies Inc. (IF:4.779)
Zhang L, Xiao M, Zhou J, Yu J. Lineage-associated underrepresented permutations (LAUPs) of mammalian genomic sequences based on a Jellyfish-based LAUPs analysis application (JBLA). Bioinformatics. 2018;34(21):3624-30. Epub 2018/05/16. doi: 10.1093/bioinformatics/bty392. PubMed PMID: 29762634. (IF:5.8)
Zhang L, Zhang S. Using game theory to investigate the epigenetic control mechanisms of embryo development: Comment on: "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev. 2017;20:140-2. Epub 2017/01/23. doi: 10.1016/j.plrev.2017.01.007. PubMed PMID: 28109753. (IF:11.7)
Zhang L, Liu Y, Wang M, Wu Z, Li N, Zhang J, et al. EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients. Journal of molecular cell biology. 2017;9(6):477-88. Epub 2017/12/23. doi: 10.1093/jmcb/mjx056. PubMed PMID: 29272522; PubMed Central PMCID: PMCPMC5907834. (IF:5.5)
Zhang L, Qiao M, Gao H, Hu B, Tan H, Zhou X, et al. Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation. Nanoscale. 2016;8(31):14877-87. Epub 2016/07/28. doi: 10.1039/c6nr01637e. PubMed PMID: 27460959. (IF:6.7)